A novel approach of drug delivery system is towards pulsatile-release pattern. Pulsatile drug delivery is one such system that, deliver drug at the right time, right place and in right amounts, holds good promises of benefit to the patients. This system is receiving increasing interest for the development of drugs whose conventional controlled drug-release systems with a continuous release are not satisfactory. This system can be classified in multiple-pulse and single-pulse systems. A popular class of single-pulse systems is that of rupturable dosage forms other systems consist of a drug-containing core, covered by a swelling layer and an outer insoluble, but semi permeable polymer coating or membrane. Pulsatile drugs involve controlled drug-release systems with a continuous release at distinct time intervals that are programmed into the drug product. Since some diseases have a predictable cyclic rhythm, the timing of medication regimens can improve the outcome of a desired effect. This condition demands development of pulsatile drug delivery system. Thus a focus on the diseases requiring Pulsatile Drug Delivery System, methodologies involved for the existing systems, recent update and Pulsatile Drug Delivery system product has a vital importance.
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